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KMID : 0376219870240030359
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Chonnam Medical Journal
1987 Volume.24 No. 3 p.359 ~ p.364
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Combined Action of Dibekacin with Cefotiam or Moxalactam against Staphylococcus aureus
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Abstract
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Minimum inhibitory concentrations (MICs) of ampicillin (AP), cefotiam (CT), methicillin(MT), moxalactam(MX),amikacin(AK),dibekacin(DK), gentamicin(GM), and kanamycin(KM) were measured against 30 strains of pathogenic Staphylococcus aureus and combined action of DK with CT or MX was examined on each tested strains using checkerboard dilution method.
Most of the tested strains were resistant to AP, DK, GM, and KM, while being susceptible to CT, MT, MX, and AK. The percentage of synergism was 63.3% in DK-CT and 40% in DK-MX combination, respectively. In the combination of DK and CT, however, the percentage of synergism on the DK-susceptible strains was significantly higher (about 20%) than that on the DK-resistant strains. No such differences were noted in the combination of DK and MX.
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KEYWORD
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